Ca and Ouabain Interaction on Vascular Smooth Muscle.

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Abstract
Summary The contracture produced by ouabain in isolated rabbit aortic strips is Ca dependent and associated with an increase in Ca45 uptake, no change in Ca content and thus presumably, an increase in Ca exchange. Ca and ouabain are also antagonistic in that the sensitivity of the tissue to ouabain can be markedly increased by placing the aortas in Ca-free Ringer's solution for a brief period. It is suggested that species sensitivity to the cardiac glycosides may be related to the level of intracellular Ca and/or the strength of Ca binding.