Lethal Mutations and Deficiencies Produced in the X-Chromosome of Drosophila melanogaster by X-Radiation

Publisher Website
Google Scholar
Abstract
Among offspring from irradiated wild-type or Theta Drosophila [male][male] mated to [female][female] carrying sex-linked, recessive markers, appeared 230 daughters with mutations or deletions involving 15 investigated loci. Markers used in common indicated variations in the frequency of mutation for the different loci, with miniature occurring most frequently. Only 128 of the mutant $? were fertile; and 112 of these mutations were lethal to sons, in many instances due to a measurable deficiency. Many tested lethals involved only a single known locus; others involved 2 or more loci, although not detectable cytologically. A large number of induced mutations are lethal even though the measurable limits of the deficiency may not exceed the locus of a mutant gene. Gene deficiencies are lethal to [male][male] and are pseudo-dominant in character as are deficient sections; however, it is difficult to prove that small deficiencies and single-locus lethals are actual losses. The induced mutant genes and single-locus lethals may differ from deficiencies; nevertheless, observed reverse mutations are not usually associated with lethal conditions.

This publication has 2 references indexed in Scilit: