Frequent somatic hypermutation of the 5' noncoding region of the BCL6 gene in B-cell lymphoma.
- 19 December 1995
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 92 (26) , 12520-12524
- https://doi.org/10.1073/pnas.92.26.12520
Abstract
The BCL6 gene encodes a zinc-finger transcription factor and is altered by chromosomal arrangements in its 5' noncoding region in approximately 30% of diffuse large-cell lymphoma (DLCL). We report here that, in 22/30 (73%) DLCL and 7/15 (47%) follicular lymphoma (FL), but not in other tumor types, the BCL6 gene is also altered by multiple (1.4 x 10(-3) -1.6 x 10(-2) per bp), often biallelic, mutations clustering in its 5' noncoding region. These mutations are of somatic origin and are found in cases displaying either normal or rearranged BLC6 alleles indicating their independence from chromosomal rearrangements and linkage to immunoglobulin genes. These alterations identify a mechanism of genetic instability in malignant B cells and may have been selected during lymphomagenesis for their role in altering BCL6 expression.Keywords
This publication has 24 references indexed in Scilit:
- The BTB/POZ domain: a new protein-protein interaction motif common to DNA- and actin-binding proteins.1995
- Cloning of bcl-6, the locus involved in chromosome translocations affecting band 3q27 in B-cell lymphoma.1993
- Clonal analysis of a human antibody response. II. Sequences of the VH genes of human IgM, IgG, and IgA to rabies virus reveal preferential utilization of VHIII segments and somatic hypermutation.The Journal of Immunology, 1993
- Deletions involving two distinct regions of 6q in B-cell non-Hodgkin lymphoma.1992
- Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin's lymphomas.1992
- Stable Expression and Somatic Hypermutation of Antibody V Regions in B-Cell Developmental PathwaysAnnual Review of Immunology, 1989
- Analysis of RAS oncogene mutations in human lymphoid malignancies.Proceedings of the National Academy of Sciences, 1988
- THE PRESENCE OF CLONOGENIC CELLS IN HIGH-GRADE MALIGNANT-LYMPHOMA - A PROGNOSTIC FACTOR1987
- Antibody diversity: Somatic hypermutation of rearranged VH genesCell, 1981
- Establishment and characterization of an Epstein-Barr virus (EBC)-negative lymphoblastoid B cell line (BJA-B) from an exceptional, EBV-genome-negative African Burkitt's lymphoma.1975