Molecular model of postsynaptic potential.
- 1 May 1975
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 72 (5) , 1749-1752
- https://doi.org/10.1073/pnas.72.5.1749
Abstract
A molecular model of the excitatory postsynaptic membrane is given in terms of two biochemical cycles intimately associated: an acetylcholine cycle and a calcium cycle. The acetylcholine controls the Na ionophores while calcium ions control the tk ionophore. The two ionophores are spatially separated but interact in such a way that the variation in K conductance precedes that in Na conductance. Digital simulation shows that our model accounts quantitatively for both the evolution of excitatory postsynaptic potential and current in a variety of experimental conditions.Keywords
This publication has 9 references indexed in Scilit:
- A Molecular Model of Action PotentialsProceedings of the National Academy of Sciences, 1974
- Effects of procaine and d-tubocurarine on the activity of membrane bound acetylcholinesteraseBiochemical Pharmacology, 1974
- An Attempt at an Integral Interpretation of Nerve ExcitabilityProceedings of the National Academy of Sciences, 1973
- An attempt at an analysis of the factors determining the time course of the end-plate currentThe Journal of Physiology, 1972
- The effect of voltage on the time course of end‐plate currentsThe Journal of Physiology, 1972
- Synaptic Electrogenesis in Eel ElectroplaquesThe Journal of general physiology, 1971
- Inhibition of membrane-bound acetylcholinesterase by d-tubocurarine and its reversal by bivalent cationsLife Sciences, 1970
- Allostérie Et Perméabilité Des Membranes CellulairesArchives Internationales de Physiologie et de Biochimie, 1970
- Cholinergic synaptic potentials and the underlying ionic mechasims.1969