Deleterious genomic mutation rate for viability inDrosophila melanogasterusing concomitant sibling controls
- 19 August 2005
- journal article
- Published by The Royal Society in Biology Letters
- Vol. 1 (4) , 492-495
- https://doi.org/10.1098/rsbl.2005.0364
Abstract
New deleterious mutations may reduce health and fitness and are involved in the evolution and maintenance of numerous biological processes. Hence, it is important to estimate the deleterious genomic mutation rate (U) in representative higher organisms. However, these estimated rates vary widely, mainly because of inadequate experimental controls. Here we describe an experimental design (the Binscy assay) with concomitant sibling controls and estimate U for viability in Drosophila melanogaster to be 0.31. This estimate, like most published studies, focuses on viability mutations and the overall deleterious genomic mutation rate would therefore be higher.Keywords
This publication has 24 references indexed in Scilit:
- Estimates of the Genomic Mutation Rate for Detrimental Alleles in Drosophila melanogasterGenetics, 2004
- Mutation accumulation and the effect of copia insertions in Drosophila melanogasterGenetics Research, 2004
- The mutational rate of Drosophila viability decline: tinkering with old dataGenetics Research, 2002
- Experimental tests of the adaptive significance of sexual recombinationNature Reviews Genetics, 2002
- Rapid mutational declines of viability in DrosophilaGenetics Research, 2001
- Sex and UTrends in Genetics, 2001
- Response to KondrashovTrends in Genetics, 2001
- The high spontaneous mutation rate: Is it a health risk?Proceedings of the National Academy of Sciences, 1997
- Deleterious mutations and the evolution of sexual reproductionNature, 1988
- Chemical mutagenesis testing in Drosophila: I. Comparison of positive and negative control data for sex‐linked recessive lethal mutations and reciprocal translocations in three laboratoriesEnvironmental Mutagenesis, 1983