VASCULAR REACTIVITY OF PERFUSED VASCULAR BED IN SPONTANEOUSLY HYPERTENSIVE AND NORMOTENSIVE RATS
- 1 February 1977
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology
- Vol. 59 (2) , 243-246
- https://doi.org/10.1111/j.1476-5381.1977.tb07485.x
Abstract
1Hypertensive and normotensive rats of the same age group were isolated from an inbred colony of spontaneously hypertensive rats.2The perfused hindquarter and mesenteric artery preparations obtained from hypertensive and normotensive rats exhibited an increased reactivity to noradrenaline (NA) and angiotensin II.3Dose‐response curves to NA obtained from hypertensive and normotensive rats exhibited a steeper slope and higher maximum than those from control rats.4These findings suggest that increased vascular reactivity of blood vessels is independent of the development or maintenance of elevated blood pressure.Keywords
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