Amine-Salt-Controlled, Catalytic Asymmetric Conjugate Addition of Various Amines and Asymmetric Protonation
- 1 May 2004
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 6 (11) , 1861-1864
- https://doi.org/10.1021/ol0493711
Abstract
The combined use of chiral Pd complex 2 and amine salt enabled completely regulated release of free nucleophilic amine. Under these conditions, an efficient catalytic asymmetric conjugate addition of various amines was achieved to afford beta-amino acid derivatives in high chemical yields with up to 98% ee. Furthermore, a highly enantioselective protonation in 1,4-addition of amine was also developed. [reaction: see text]Keywords
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