Reovirus Type 3 Associated with Fatal Pneumonia

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Abstract
REOVIRUSES have been isolated from specimens obtained from children or adults who appear well1 or have had upper-respiratory-tract infection,2 3 4 5 6 7 pneumonia,8 , 9 nonspecific febrile illness,5 exanthem,3 , 8 , 10 , 11 diarrhea,5 , 6 , 12 hepatitis,8 meningoencephalitis,4 , 8 , 13 , 14 and Burkitt's lymphoma.15 In some of these cases a concomitant rise in type-specific antibodies to reoviruses has been documented. 2 , 7 , 8 , 10 , 14 However, their role in human disease is still unclear. Rarely have deaths been associated with these infections.8 , 13 We report below the first definitive association of reovirus infection with fatal nonbacterial pneumonia.Case ReportL.J. a 5-year-old Negro girl, entered the Detroit General Hospital on February 19, 1965, with fever, rhinorrhea and a nonproductive cough. . . .