Human pharmacokinetics of acyclovir (an antiviral agent) following rapid intravenous injection

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Abstract
Acyclovir [9-(2 hydroxyethoxymethyl)guanine] an acyclic nucleoside of guanine with potent antiviral activity against the herpes simplex virus both in vitro and topically in man was injected as a bolus intravenously in six healthy volunteers at a mean dose of 0·73 mg/kg after some preliminary slower infusions. Pharmacokinetic data were obtained to aid the design of therapeutic regimens. The drug is excreted principally by the kidneys, principally unchanged, thereby retaining its viricidal activity, and at a rate greater than the glomerular filtration rate. The disposition rate was of the order of 3 h. No signs of intolerance appeared.