Synthesis of serum glycoproteins in response to injury

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Abstract
The transient elevations in rat serum globulins in response to injury were studied by precipitating the seromucoid fraction following the intraperitoneal injection of C14-labeled algal hydrolysate and C14-labeled glycine. Rats, injured by sponge implantation, showed a parallel increase in seromucoid protein and radioactivity. Partial hepatectomy, which reduced the response to stress, yielded a seromucoid fraction of high specific activity when the labeled amino acid was injected 2 hr prior to sacrifice. Chemical hepatic necrosis, produced by administration of carbon tetrachloride, reduced the level of the seromucoid fraction. Subsequent injury yielded a striking response both in the seromucoid protein and in the amount of seromucoid radioactivity. It is concluded that these data are consistent with an active synthesis of protein in response to injury.