Induction of Drug-Metabolizing Enzymes: A Path to the Discovery of Multiple Cytochromes P450
- 1 April 2003
- journal article
- other
- Published by Annual Reviews in Annual Review of Pharmacology and Toxicology
- Vol. 43 (1) , 1-30
- https://doi.org/10.1146/annurev.pharmtox.43.100901.135754
Abstract
This article provides a personal account of the discovery of the induced synthesis of drug-metabolizing enzymes and of subsequent research that led to the discovery of multiple cytochromes P450 with different catalytic activities. The manuscript also emphasizes the role of environmental factors (in addition to genetic polymorphisms) in explaining person-to-person and day-to-day differences in rates and pathways of drug metabolism that occur in the human population.Keywords
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