MIDAZOLAM ACTS SYNERGISTICALLY WITH FENTANYL FOR INDUCTION OF ANAESTHESIA

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Abstract
The induction dose—response of midazolam was compared with the dose—response of its combination with fentanyl and with that of fentanyl alone in three groups of 60 unpremedicated, ASA physical status I or II women undergoing minor gynaecological surgery. The end-point of induction of anaesthesia was inability to open eyes upon command. Dose—response curves were determined for each group with a probit procedure and compared with an isobolographic analysis. Midazolam was found to act in synergism with fentanyl for induction of anaesthesia. Twenty-five percent of the ED50 of fentanyl was required in combination with 23% of the ED50 for midazolam to achieve the ED50 of the combination. This degree of synergism may explain mutual potentiation between opioids and benzodiazepines reported previously