Antimicrosomal antibodies, gastric parietal cell antibodies and antinuclear factors in insulin dependent diabetes mellitus.

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Abstract
Thyroid antimicrosomal antibodies, gastric parietal cell antibodies (PCA) and antinuclear factors were studied in 208 insulin-dependent diabetics (IDD), according to the duration of diabetes and patient''s age at the time of testing. Antimicrosomal antibodies were found in 11 of 47 (23.4%) IDD with a duration of < 1 yr; this value declined to 13.1% at 1-3 yr, 15.3% at 4-5 yr, 10.8% at 6-10 yr and 5.8% at > 10 yr. Of the 47 IDD, 7 (14.8%) were positive for gastric parietal cell antibodies. Prevalence of PCA declined with increasing duration of diabetes. This decrease in prevalence of antimicrosomal antibodies and PCA was not so extreme as that of pancreatic islet cell antibodies. Antinuclear factors did not reveal significant correlation with duration of diabetes. In normal controls, prevalence of antimicrosomal antibodies, PCA and the antinuclear factors increased progressively with age. In IDD, prevalence of antinuclear factors was also progressively greater with age. Prevalence of antimicrosomal antibodies in IDD decreased with age and those of PCA showed the lowest percent in the 40-69 yr age group.