Effect of Intranasally Administered Immune Serum on Influenza Virus Present in the Mouse Lung.

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Abstract
When mice were infected by the intranasal route with large doses of influenza virus and immune serum was introduced into the lungs 1 hr. later, the animals died even though neither the amt. of infectious virus in the lungs at the time the serum was given nor the amt. subsequently produced was as great as the corresponding amts. found in the lungs of mice that had been infected with small doses of virus and that were protected when immune serum was given 24 hrs. later. The findings suggest that a large amt. of influenza virus introduced directly into the mouse lung may, by itself, be sufficient to kill the animal without any subsequent multiplication of the agent.