Fluoride Metabolism in Pregnant Rats.

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Abstract
Summary The F metabolism was compared in pregnant and non-pregnant rats of 170 g weight. In the bones, F content was similar in both groups, and when F supply exceeded 14.55 ppm, there was a pronounced increase in bone F content. In fetal bones, the increase appeared at lower levels of supply, i.e. 5.2-14.55 ppm. In the blood, F levels were similar in pregnant and non-pregnant rats. At intakes exceeding 14.55 ppm, there was only a slight increase in blood F in both groups. In the urine, F levels increased in both groups similarly, and rather steeply with increased F intake, thus indicating immediate removal of any F surplus with the urine in pregnant and non-pregnant rats. It is stressed that this metabolism is different from that observed in pregnant women, who tend to retain an F surplus-during pregnancy.

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