Characterization of the plasmidic beta-lactamase CMY-2, which is responsible for cephamycin resistance
- 1 January 1996
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 40 (1) , 221-224
- https://doi.org/10.1128/aac.40.1.221
Abstract
The phenotype of Klebsiella pneumoniae HEL-1 indicates a plasmidic cephamycinase gene (blaCMY-2). Its sequence shows one open reading frame coding for a protein of 381 amino acids. CMY-2 is classified as class C beta-lactamase that is closely related to the plasmidic enzymes BIL-1 and LAT-1 and the chromosomal AmpC of Citrobacter freundii. The blaCMY-2 gene possibly was translocated onto a plasmid of C. freundii which spread to K. pneumoniae.Keywords
This publication has 15 references indexed in Scilit:
- A functional classification scheme for beta-lactamases and its correlation with molecular structureAntimicrobial Agents and Chemotherapy, 1995
- Gene sequence and biochemical characterization of FOX-1 from Klebsiella pneumoniae, a new AmpC-type plasmid-mediated beta-lactamase with two molecular variantsAntimicrobial Agents and Chemotherapy, 1994
- Cloning and sequence analysis of blaBIL-1, a plasmid-mediated class C beta-lactamase gene in Escherichia coli BSAntimicrobial Agents and Chemotherapy, 1994
- Characterization of a plasmid-borne and constitutively expressed blamox-1 gene encoding AmpC-type β-lactamaseGene, 1994
- Identification of a novel plasmid-mediated β-lactamase with chromosomal cephalosporinase characteristics from Klebsiella pneumoniaeJournal of Antimicrobial Chemotherapy, 1993
- Novel plasmid-mediated beta-lactamase (MIR-1) conferring resistance to oxyimino- and alpha-methoxy beta-lactams in clinical isolates of Klebsiella pneumoniaeAntimicrobial Agents and Chemotherapy, 1990
- Fast and sensitive multiple sequence alignments on a microcomputerBioinformatics, 1989
- Biochemical Characterization of Type A and Type B -Lactamase from Enterobacter cloacaeClinical Infectious Diseases, 1988
- The structure of β-lactamasesPhilosophical Transactions of the Royal Society of London. B, Biological Sciences, 1980
- The Use of Analytical Isoelectric Focusing for Detection and Identification of -LactamasesJournal of General Microbiology, 1975