Antitumor activity of ilmofosine (BM 41.440) in the3Lewis‐lung carcinoma model

Publisher Website
Google Scholar
Abstract
Ilmofosine (1-hexadecylthio-2-methoxymethyl-1,3-propanediol-phosphocholine, BM 41.440) is a thioether phospholipid with cytostatic/cytotoxic properties. The antineoplastic activity of this compound was investigatedin vivo in the3Lewis-lung carcinoma system.3Lewis lung tumor-bearing C57Bl/6 mice were treated with 0.625 to 40 mg Il-mofosine/kg per dayp.o. either from days 1 to 9 or from days 11 to 28 after intrafoot-pad tumor cell inoculation. Ilmofosine caused a significant dose-related response on tumor growth and metastases, expressed in terms of tumor diameter, tumor weight, survival time and number of metastases-free animals as compared to sham-treated and positive (cyclophosphamide) controls. The results suggest that direct cytostatic/cytotoxic effects, rather than immune-modulatory mechanisms, preferentially contribute to the antitumor activity of Ilmofosinein vivo.