Modulation of chemical carcinogenesis in rats by alkyl lysophospholipids
- 1 November 1987
- Vol. 22 (11) , 935-942
- https://doi.org/10.1007/bf02535559
Abstract
The influence of 1‐O‐octadecyl‐2‐O‐methyl‐rac‐glycero‐3‐phosphocholine (ET‐18‐OCH3) and 1‐hexadecylmercapto‐2‐methoxymethyl‐rac‐propyl‐3‐phosphocholine (TLP, BM41.440) on methylnitrosourea (MNU)‐induced rat mammary carcinomas and of ET‐18‐OCH3 on 7,12‐dimethylbenzanthracene (DMBA)‐induced leukemias was investigated. Both agents effectively delayed MNU‐induced mammary tumor formation at high, cytotoxic dosages but TLP had no influence at low “immunomodulatory” doses. ET‐18‐OCH3 also significantly protected against leukemia development in DMBA‐treated Long‐Evans rats.Keywords
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