Chemotherapy of autochthonous leukemias induced by 7,12-dimethylbenz(a)anthracene in long evans rats
- 1 March 1980
- journal article
- research article
- Published by Springer Nature in Zeitschrift für Krebsforschung und Klinische Onkologie
- Vol. 96 (2) , 157-162
- https://doi.org/10.1007/bf00405500
Abstract
A total of 111 autochthonous (primary) acute rat leukemias of the diffuse-hepatic type which had been induced by 7,12-dimethylbenz(a)anthracene were treated with mono- and combination chemotherapy. The survival time of treated rats increased significantly compared to untreated controls. A combination of vincristine (VCR), adriamycin (ADR), and cytosine arabinoside (Ara-C) was superior to a combination of VCR and ADR as well as to a monotherapy with Cyclophosphamide, BCNU, VCR, ADR, and Ara-C.Keywords
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