Effect of halogenmethylenebisphosphonates on bone cells in culture and on bone resorption in vivo
- 1 March 1986
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 42 (3) , 302-304
- https://doi.org/10.1007/bf01942514
Abstract
Dihalogenmethylenebisphosphonates increase alkaline phosphatase activity and fatty acid oxidation in calvaria cells in culture (Cl2MBP>Br2MBP≊F2MBP). The monohalogen C1MBP and the non-halogenated analogues are less active on phosphatase and inactive on or inhibitory towards fatty acid oxidation. The three dihalogenbisphosphonates and C1MBP inhibit bone resorption in vivo, Cl2MBP most strongly.Keywords
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