Antiviral activity of phorbol myristate acetate and possible relationships with interferon action

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Abstract
Signal‐induced turnover of membrane phospholipids represents a fundamental transducing mechanism that induces a signal cascade resulting in mobilization of calcium, activation of protein kinase C by diacylglycerol, release of arachidonic acid and stimulation of cyclic GMP production. In this pathway tumor‐promoting phorbol esters such as phorbol myristate acetate (PMA) may substitute for diacylglycerol. The interferonlike antiviral effect of PMA described here suggests that the inositol phospholipid‐diacylglycerol‐protein kinase C signal‐transducing mechanism may be involved in interferon action.