Association between HLA‐B7 and Allergic Reactions to Insulin in Insulin‐Dependent Diabetes Mellitus
- 1 October 1977
- journal article
- research article
- Published by Wiley in Tissue Antigens
- Vol. 10 (4) , 273-277
- https://doi.org/10.1111/j.1399-0039.1977.tb00757.x
Abstract
Forty-four cases of insulin-dependent diabetes mellitus with cutaneous allergic reactions to insulin were typed for HLA-A and -B antigens. HLA-B7, which commonly is negatively associated with insulin-dependent diabetes mellitus, showed a positive association with insulin allergy. A 2nd antigen, HLA-BW21 may also be positively associated with local insulin allergy. These data were discussed in relation to heterogeneity of insulin-dependent diabetes mellitus and to the existence of B7-associated immune response genes for allergic immunoreactivity to insulin.This publication has 6 references indexed in Scilit:
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