Lymphokine mRNA and T cell multireceptor mRNA of the Ig super gene family are reciprocally modulated during human T cell activation

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Abstract
The expression of genes, implicated in T cell proliferation as well as those coding for the three chains of the T cell receptor (TcR) and for the CD4 and CD8 molecules, has been investigated during activation of various T cell populations maintained in long‐term culture. We show that a minimal activation signal, capable of inducing inter‐leukin 2 (IL2) receptor expression without the expression of IL2 and interferon‐γ, was not associated with a down‐regulation of the messengers coding for the T cell multireceptor molecules. In contrast, a strong activation signal via the TcWCD3 complex or via the CD2 molecule resulted in a reciprocal transient up‐regulation of the messengers implicated in T cell proliferation and a down‐regulation of the messengers encoding the molecules of the TcR complex of the immunoglobulin super gene family.