Natural killer cells, viruses and cancer
Top Cited Papers
- 1 October 2001
- journal article
- review article
- Published by Springer Nature in Nature Reviews Immunology
- Vol. 1 (1) , 41-49
- https://doi.org/10.1038/35095564
Abstract
Natural killer cells are innate immune cells that control certain microbial infections and tumours. The function of natural killer cells is regulated by a balance between signals transmitted by activating receptors, which recognize ligands on tumours and virus-infected cells, and inhibitory receptors specific for major histocompatibility complex class I molecules. Here, we review the emerging evidence that natural killer cells have an important role in vivo in immune defence.Keywords
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