URINARY-BLADDER TUMORS INDUCED BY N-BUTYL-N-(4-HYDROXYBUTYL)NITROSAMINE IN DOGS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 41  (5) , 1958-1966
Abstract
Clinicopathological, radiological and histological studies were performed on urinary bladder neoplasia induced by N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in 5 adult beagle dogs and in 10 adult mongrel dogs. Tumors of the urinary bladder developed in dogs given various daily doses of BBN p.o. (per os) for different periods. The latent period of tumor induction was 4 yr in dogs receiving a daily dose of 80 mg of BBN, 2-2.5 yr in dogs receiving a daily dose of 160 mg of BBN and 1.5 yr in dogs receiving a daily dose of 240 mg of BBN. The total dose of BBN ingested by the dogs until the 1st tumors were observed by urological examinations was nearly the same in all groups, 100-140 g. There apparently is a correlation between dose and induction time but further dose-response studies are required. Histologically, tumors of the urinary bladder were transitional cell papillomas or transitional cell carcinomas resembling morphologically those found in human cases. It is possible to observe the process of development of urinary bladder tumors from initial lesions to invasive tumors using routine urological examinations. This experimental model is valuable for clinicopathological studies of urinary bladded tumors.