Hepatic lipase
- 1 June 1999
- journal article
- review article
- Published by Wolters Kluwer Health in Current Opinion in Lipidology
- Vol. 10 (3) , 259-268
- https://doi.org/10.1097/00041433-199906000-00008
Abstract
Hepatic lipase catalyses the hydrolysis of triglycerides and phospholipids in all major classes of lipoproteins. Genetic deficiency of this enzyme is associated with a unique plasma lipoprotein profile, characterized by hypertriglyceridemia and elevated concentrations of intermediate density lipoproteins and HDL. Recent studies have identified common polymorphisms in the hepatic lipase gene that are associated with low hepatic lipase activity and increased concentrations of large HDL. Association studies using these polymorphisms are elucidating the effects of variation in hepatic lipase activity on plasma lipoprotein concentrations and susceptibility to coronary atherosclerosis.Keywords
This publication has 49 references indexed in Scilit:
- The role of hepatic lipase in lipoprotein metabolism and atherosclerosisCurrent Opinion in Lipidology, 1998
- A hepatic lipase ( LIPC ) allele associated with high plasma concentrations of high density lipoprotein cholesterolProceedings of the National Academy of Sciences, 1997
- New aspects on the role of plasma lipases in lipoprotein catabolism and atherosclerosisAtherosclerosis, 1996
- Activities of lipoprotein lipase and hepatic triglyceride lipase in postheparin plasma of patients with low concentrations of HDL cholesterol.Arteriosclerosis and Thrombosis: A Journal of Vascular Biology, 1993
- Triacylglycerol and phospholipid hydrolysis in human plasma lipoproteins: role of lipoprotein and hepatic lipaseBiochemistry, 1992
- Relationship between Post-Heparin Plasma Lipases, Triglycerides and High Density Lipoproteins in Normal SubjectsHormone and Metabolic Research, 1990
- Postheparin plasma lipoprotein and hepatic lipase are determinants of hypo- and hyperalphalipoproteinemia.Journal of Lipid Research, 1989
- Human hepatic triglyceride lipase: cDNA cloning, amino acid sequence and expression in a cultured cell lineDifferentiation, 1987
- Postheparin plasma triglyceride lipases. Relationships with very low density lipoprotein triglyceride and high density lipoprotein2 cholesterol.Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1985
- Hydrolysis of human plasma high density lipoprotein2-phospholipids and triglycerides by hepatic lipaseBiochemical and Biophysical Research Communications, 1981