Posttranslational attenuation of peptide gene expression
- 30 July 1990
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 268 (1) , 1-4
- https://doi.org/10.1016/0014-5793(90)80957-k
Abstract
Studies of the cell-specific processing of neuroendocrine peptides have shown that neuroendocrine cells occasionally fail to mature the biosynthetic precursors to bioactive peptides, or that they do so to a negligible extent only. Instead, inactive precursors and processing intermediates accumulate in the cells. Thus, the expression of genes encoding hormonal peptides is in certain cells and under certain conditions attenuated at the posttranslational level. The exact molecular mechanisms of posttranslational atenuation are still largely unknown. The review emphasizes that postttranslational attenuation may play a significant role during normal cell differentiation and in the carcinogenic transformation of cells. The existence of post-translational attenuation has significant biological and clinical implicationsKeywords
This publication has 26 references indexed in Scilit:
- Characterization of gastrin amidation in the rat and porcine antrum: comparison with the pituitaryRegulatory Peptides, 1990
- Peptide α-AmidationAnnual Review of Physiology, 1988
- Cell-specific processing of pro-cholecystokinin and pro-gastrinBiochimie, 1988
- The processing of peptide precursorsFEBS Letters, 1986
- β-Endorphin is processed differently in specific regions of rat pituitary and brainNature, 1982
- N-Acetylation Regulates the Behavioral Activity of α-Melanotropin in a Multineurotransmitter NeuronScience, 1982
- Attenuation in the control of expression of bacterial operonsNature, 1981
- Selective processing of β-endorphin in regions of porcine pituitaryNature, 1980
- Autocrine Secretion and Malignant Transformation of CellsNew England Journal of Medicine, 1980
- Pancreatic gastrin in foetal and neonatal ratsNature, 1976