ERYTHROID CELL MATURATION AND HEMOGLOBIN SYNTHESIS IN MEGALOBLASTIC ANEMIA*

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Abstract
Glycine-2-C14 and Fe59 were used as tracers in studies of 3 patients with megaloblastic erythropoiesis due to pernicious anemia. One was treated with vitamin B12 at the time of isotope administration. The data indicate that the maturation time of the primitive megaloblast is prolonged. The prolongation may be more marked at an early stage of maturation and become more nearly normal as the cell matures. Heme and globin synthesis appear to be synchronous during maturation of the megaloblastic cell. Vitamin B12 appears to shorten the maturation time and may enhance globin synthesis in the primitive cell.