Pleiotropic Effects of a Butyrolaetone-type Autoregulator on Mutants of Streptomyces griseus Blocked in Cytodifferentiation

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Abstract
Mutants of S. griseus blocked in cytodifferentiation regained their capacity to form differentiated mycelia and/or anthracycline pigments in the presence of butyrolactone-type autoregulatory effectors such as trans-2-(6''-methylheptanol-1''-yl)-3-hydroxymethyl-4-butanolide. The effect was correlated with an increase in lipid synthesis, with changes in the composition of lipid fraction and with the restoration of the production of neutral proteinases. Apparently, autoregulatory butyrolactones from streptomycetes stimulate cytodifferentiation of their producers at an early stage of development.