Murine alloantigen acquisition by schistosomula of Schistosoma mansoni: Further evidence for the presence of K, D, and I region gene products on the tegumental surface

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Abstract
Schistosomula, recovered from the lungs of S. mansoni-infected mice, acqure H-2Kk and both Ik and Is gene products. Several individual antigenic specificities were identified while mapping, not only to H-2Kk and I-Ak (Sher, et. al., 1978), but to H-2Dk, I-Ek, H-2Kb, H-2Db and I-Ab as well. Private H-2 specificities 23 (H-2Kk) and 32 (H-2Dk) were identified on the tegumental surface of schistosomula isolated from C3H/Crgl mice (H-2k). Larvae isolated from C57Bl/10Sn (B10) mice (H-2b) acquired private specificities 33 and 2, which map to H-2Kb and H-2Db, respectively. I region associated (Ia) antigens coded for by genes mapping in the I-A subregion (Ia.2 and 3) and I-E subregion (Ia.7) were also acquired from C3H/Crgl mice. Schistosomula from B10 donors acquire Ia specificities 3 and 8, which are under I-A subregion control. Evidence that monoclonal antibodies recognize H-2 antigens on the larval surface is presented.