Phenylbutazone: Factors Influencing Plasma Concentrations
- 1 March 1977
- journal article
- Published by SAGE Publications in Journal of International Medical Research
- Vol. 5 (2_suppl) , 15-19
- https://doi.org/10.1177/030006057700502s04
Abstract
The author points out that whilst the total metabolic fate of phenylbutazone in man is better understood, discrepancies between single and multiple dose half-lives, as shown in the studies described, still remain to be explained. It is concluded that the mechanism responsible for limiting the plasma concentration of phenylbutazone when doses are increased requires further study.Keywords
This publication has 12 references indexed in Scilit:
- Increased oxidation of phenylbutazone during hydrocortisone infusion in man.Published by Wiley ,1977
- Plasma concentration of phenylbutazone and its therapeutic effect- studies in patients with rheumatoid arthritis.Published by Wiley ,1976
- The Metabolism of Phenylbutazone in the RatXenobiotica, 1974
- MECHANISM OF HEPATIC DRUG OXIDATION AND ITS RELATIONSHIP TO INDIVIDUAL DIFFERENCES IN RATES OF OXIDATION IN MAN*Annals of the New York Academy of Sciences, 1971
- Individual Differences in the Plasma Half‐lives of Lipid Soluble Drugs in ManActa Pharmacologica et Toxicologica, 1971
- Genetic Control of Phenylbutazone Metabolism in ManBMJ, 1970
- Genetic Control of Drug Levels in Man: PhenylbutazoneScience, 1968
- Blood Levels of Drug at the Equilibrium State after Multiple DosingNature, 1965
- Observations on the antirheumatic and physiologic effects of phenylbutazone (butazolidin) and some comparisons with cortisoneThe American Journal of Medicine, 1954
- PHENYLBUTAZONE THERAPY: RELATION BETWEEN THE TOXIC AND THERAPEUTIC EFFECTS AND THE BLOOD LEVELThe Lancet, 1954