Analysis of the promoter region and the N-propeptide domain of the human proα2(I) collagen gene
Open Access
- 1 January 1985
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 13 (10) , 3427-3438
- https://doi.org/10.1093/nar/13.10.3427
Abstract
We have located the exon coding for the start site of transcription of the human proα2(I) collagen gene. Comparison with the homologous region of other fibrillar collagen genes has confirmed the existence of a consensus sequence (CATGTCTA-n-TAGACATG) capable of forming a hairpin secondary structure possibly involved in the regulation of collagen biosynthesis. Sequence comparison of the chronosomal regions at the 5′ end of the proα1(I) and proα2(I) collagen genes failed to identify unique DNA elements potentially mediating comon regulatory siguals. Sequencing of four exons coding for the N-terminal propeptide has determined most of its structure and it has implied the existence of smaller coding units similar to the 11 end 18 bp exons originally described in the avien gene.Keywords
This publication has 20 references indexed in Scilit:
- Evidence for a structural mutation of procollagen type I in a patient with the Ehlers-Danlos syndrome type VII.Published by Elsevier ,2021
- Analysis of the 3' end of the human pro-alpha 2(I) collagen gene. Utilization of multiple polyadenylation sites in cultured fibroblasts.Journal of Biological Chemistry, 1983
- Synthesis of a shortened pro-alpha 2(I) chain and decreased synthesis of pro-alpha 2(I) chains in a proband with osteogenesis imperfecta.Journal of Biological Chemistry, 1983
- Chick proα2 (I) collagen gene; exon location and coding potential for the prepropeptideNucleic Acids Research, 1983
- Enhanced graphic matrix analysis of nucleic acid and protein sequences.Proceedings of the National Academy of Sciences, 1981
- Structure of the promoter for chicken alpha 2 type I collagen gene.Proceedings of the National Academy of Sciences, 1981
- Structurally Distinct Collagen TypesAnnual Review of Biochemistry, 1980
- Spliced early mRNAs of simian virus 40Proceedings of the National Academy of Sciences, 1978
- Levels of translatable mRNAs for cell surface protein, collagen precursors, and two membrane proteins are altered in Rous sarcoma virus-transformed chick embryo fibroblasts.Proceedings of the National Academy of Sciences, 1977
- A new method for sequencing DNA.Proceedings of the National Academy of Sciences, 1977