Alteration of T-Lymphocyte Subpopulations in Patients with Primary Renal Diseases and Systemic Lupus Erythematosus

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Abstract
Patients (48) with a variety of primary renal diseases and systemic lupus erythematosus (SLE) were examined for the proportion of circulating T [thymus-derived] lymphocytes bearing receptors for Ig[immunoglobulin]M (T.mu. cells) or IgG (T.gamma. cells). Although the control group showed strikingly similar mean values for T.mu. and T.gamma. cells, the whole group of patients with primary renal diseases and SLE showed a wide scatter of values. Sixteen patients with primary renal diseases and SLE showed a wide scatter of values. Sixteen patients with primary renal diseases and SLE had higher proportions of T.gamma. cells than the control group, whereas 7 patients with chronic glomerulonephritis (CGN), membranoproliferative glomerulonephritis (MPGN), lipoid nephrosis (LN), and SLE showed very marked decrease in proportions of T.gamma. cells in the peripheral blood. Six out of the total group of patients had low proportions of T.mu. cells in the peripheral blood. No consistent relationship between the proportion of T.mu. and T.gamma. cells was found. There apparently exist a heterogeneity of T lymphocyte subpopulation distribution in some patients with primary renal diseases and SLE. The possible significance of these phenomenon in the pathophysiology of renal diseases was discussed.