Studies of Cell-Mediated Immunity in Human Glomerulonephritis by Macrophage Migration Inhibition Test

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Abstract
Using the macrolhage migration inhibition test (MIT), a total of 113 patients with glomerulonephritis (GN) were studied for evidence of cell-mediated immunity to various soluble antigens prepared. The positive rate of MIT in the presence of streptococcal antigen, glomerular basement membrane antigen, renal tubular epithelial antigen and heat-aggregated Ig[immunoglobulin]G antigen was 15, 23, 16 and 15%, respectively. Of 15 positive patients who were able to be evaluated with those 4 antigens, 9 cases exhibited cellular hypersensitivity to 2 or more antigens at the same time. There may be an abnormal cellular response to certain antigen or widespread cell-mediated hypersensitivity to a variety of antigens in certain forms of human GN.