Substrate and Inhibitor Profile of BACE (β-Secretase) and Comparison with Other Mammalian Aspartic Proteases
Open Access
- 1 February 2002
- journal article
- Published by Elsevier
- Vol. 277 (7) , 4687-4693
- https://doi.org/10.1074/jbc.m109266200
Abstract
No abstract availableKeywords
This publication has 28 references indexed in Scilit:
- BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeuticsHuman Molecular Genetics, 2001
- Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generationNature Neuroscience, 2001
- ASP1 (BACE2) Cleaves the Amyloid Precursor Protein at the β-Secretase SiteMolecular and Cellular Neuroscience, 2000
- BACE2, a β-secretase homolog, cleaves at the β site and within the amyloid-β region of the amyloid-β precursor proteinProceedings of the National Academy of Sciences, 2000
- Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor proteinProceedings of the National Academy of Sciences, 2000
- The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the Down critical regionFEBS Letters, 2000
- Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activityNature, 1999
- Purification and cloning of amyloid precursor protein β-secretase from human brainNature, 1999
- Identification of a Novel Aspartic Protease (Asp 2) as β-SecretaseMolecular and Cellular Neuroscience, 1999
- β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACEScience, 1999