Studies of oxidative stress in cellular systems The interaction of monocytes and erythrocytes
Open Access
- 17 December 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 314 (3) , 455-457
- https://doi.org/10.1016/0014-5793(92)81525-q
Abstract
1H spin echo NMR spectroscopy is used to follow the interaction of intact and viable erythrocytes and monocytes obtained from different sources in mixed cultures. After a lag time (270 min) erythrocyte glutathione is observed to become more oxidised. This result is believed to occur as a consequence of monocyte activation generating hydrogen peroxide or hypochlorous acid, which is targeted at the erythrocyte. The red cell in turn employs its sulphydryl system as an anti‐oxidant defence.Keywords
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