Immunohistochemical analysis of bone morphogenetic protein (BMP) in osteosarcoma

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Abstract
The monoclonal antibody against bovine bone morphogenetic protein (bBMP‐McAb) was first used for demonstration of bone morphogenetic protein (BMP) in osteosarcoma. The avidin‐biotin complex method (ABC) demonstrated that of the 18 osteosarcomas, 15 stained positive, while all 6 fibrosarcomas were negative. The results showed that BMP mainly exists in the tumor cell plasma and some tumor‐like bone tissues. Using this staining method, we can not only differentiate osteosarcoma from fibrosarcoma and other non‐bone‐derived tumors, but also classify osteosarcoma according to the content and distribution of BMP and the patient's clinical situation, thus providing a scientific basis for clinical treatment.