Prosthetic valve endocarditis caused by Histoplasma capsulatum

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Abstract
Previously reported cases of H. capsulatum infection of prosthetic heart valves have been first diagnosed at autopsy. A patient had an H. capsulatum infection that was diagnosed by serologic means 1 1/2 yr before involvement of the patient''s prosthetic mitral valve was found at surgery. Numerous previous attempts to demonstrate organisms by culture and histologic study of bone marrow and liver biopsy specimens were unsuccessful. Various serologic tests were used in the diagnosis and evaluation of treatment of H. capsulatum endocarditis. The management of this case was compared with other previously reported cases of endocarditis caused by H. capsulatum.