B cell progenitors have different growth requirements before and after immunoglobulin heavy chain commitment.

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Abstract
Using the clonable pre-B cell assay, we have identified B cell progenitors that are not yet committed to the production of a particular H chain allele. These cells represent .apprx. 10-20% of clonable pre-B cells found in 15-d fetal liver. The clonable pre-Bcell assay provides an enviromnent adequate for the expansion and differentiation of these cells into mature, Ig-secreting, cells. Using the same methodology, we have also identified progenitors that are uncommitted to the production of a particular L chain isotype. Moreover, investigating the growth requirements for clonable pre-B cells has led to the discovery of selective growth conditions that distinguish cells before and after commitment to H chain allotype.

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