The Effect of Serotonin and Transcapillary Pressure on the Capillary Permeability in therete mirabileof the Eel (Anguilla vulgarisL.)

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Abstract
Measurements of transcapillary exchange of high‐molecular dextrans, K+ and THO in therete mirabileof eel (Anguilla vulgaris L.) have been made under steady‐state conditions while the transcapillary pressure was varied and pharmaca added to the perfusates. Raising the transcapillary input pressure increased the exchange of dextrans and K+ but lowered that of THO. Histamine and ouabain had no effect on the transcapillary exchange of the test molecules. The highest dose (100 μg/ml) of serotonin reversibly increased the capillary permeability of D‐75 000, K+and THO while the medium dose (50 μg/ml) only raised the transcapillary exchange of K+and THO. The lowest dose (10 μg/ml) had no permeability effect. Our main conclusion is that serotonin reversibly increases the area of the intercellular pores by affecting the capillary wall directly.