Biochemistry of Uric Acid and Its Relation to Gout

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Abstract
HyperuricemiaUric Acid MetabolismSo far as is known today, uric acid serves no biochemical function in the body other than being an end product of purine metabolism. The metabolically important purines, adenine and guanine, serve as building blocks for nucleic acids and as components of cofactors for a wide variety of biochemical reactions. Adenine and guanine originate either from dietary purines or from a de novo biosynthesis. The purines formed in excess of the body's requirements, as well as a portion of those arising from tissue catabolism, undergo an irreversible oxidation to uric acid. Purine biosynthesis in bacteria has . . .