The influence of the presence of glucose during growth on the enzymic activities of Escherichia coli: comparison of the effect with that produced by fermentation acids

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Abstract
The presence of glucose in the medium during the growth of E. coli suppresses the formation of certain enzymes; the degree of inhibition is greater than, or bears no relation to, the effect produced by growth in a medium adjusted to the final pH produced in glucose media by fermentation acids. Neutralization of fermentation acids during growth does not alter the degree of inhibition of deaminase formation produced by glucose. The reduction of the activity of certain enzymes as a result of growth in glucose is not a permanent change in the enzyme constitution of the cell as it is removed immediately growth takes place in the absence of fermentable carbohydrate. The presence of glucose in liquid growth media has no effect upon the urease, catalase and fumarase activities of Micrococcus lysodeikticus.