Evaluation and Limitations of the Perchlorate Test in the Study of Thyroid Function

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Abstract
A study of the perchlorate (KClO4) test in 281 patients has led to the following observations: the test may be considered significant when thyroidal radioiodine content (2 hr after the dose) falls more than 5% 1 hr after KClO4; positive tests were encountered in 9 patients with sporadic goitrous cretinism, in 11 nontoxic goiters, in 21 prenatal deaf-mutes without goiter, and in 7 patients with Pendred's syndrome. A significant incidence of positive KClO4 tests has been found in relatives (9 out of 42) of 13 patients with positive KClO4 tests; on the other hand, no significant incidence of positivity was found in family members (1 out of 27) of 17 patients with negative KClO4 tests. The positivity in parents and siblings suggests the possiblity of autosomal dominant transmission of this character.

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