Interleukin 2-dependent release of interleukin 3 activity by T4+ human T-cell clones.
- 1 October 1985
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 82 (20) , 7020-7024
- https://doi.org/10.1073/pnas.82.20.7020
Abstract
We have isolated and studied two alloreactive, T4+, human lymphocyte clones that release interleukin 2 (IL-2) and interleukin 3 (IL-3) bioactivities upon stimulation with IL-2, alloantigen, or Sepharose-conjugated antibodies directed against the T3 protein. Anti-IL-2 receptor monoclonal antibodies block IL-2-, alloantigen-, or anti-T3-stimulated IL-3 release. Hence, release of IL-3 activity in each circumstance is rigorously dependent upon activation of the IL-receptor. Even low, nonmitogenic concentrations of recombinant IL-2 stimulated IL-3 release.Keywords
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