Differential Effects of the Dopamine Antagonist Remoxipride on Apomorphine Induced Behaviour in the Rat

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Abstract
The effects of the novel substituted benzamide remoxipride on apomorphine induced behavior in rats was investigated by means of an automatic holeboard apparatus. The ability of remoxipride to antagonize locomotion and gnawing induced by a high dose of apomorphine (5 mg/kg) and inhibition of exploration induced by a low dose of apomorphine (0.05 mg/kg) was tested. It was found that remoxipride in moderate doses potentiate locomotion and inhibit gnawning induced by the high dose of apomorphine while higher doses of remoxipride inhibits both apomorphine induced gnawing and locomotion. The inhibition of exploration following the low dose of apomorphine was not antagonized by remoxipride pretreatment. The results demonstrated that remoxipride has an interesting and unique profile of dopamine antagonistic effects in rat behavioral models.