SCANNING AND TRANSMISSION ELECTRON-MICROSCOPIC STUDY OF EQUINE INFECTIOUS-ANEMIA VIRUS

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 39  (5) , 731-740
Abstract
Scanning and transmission electron microscopy were used to study in detail the morphogenesis and replication of equine infectious anemia virus (EIAV) in cultured, persistently infected equine fetal kidney fibroblasts. The EIAV was shown by thin-section EM to resemble morphologically more closely the members of the genus Lentivirus in the family Retroviridae than other genera. Scanning electron microscopy demonstrated budding virus on only about 5% of the equine fetal kidney fibroblasts; however, the entire surface of these cells was involved in viral replication. Except where virus budding was observed, EIAV-infected cells were smooth and free of the topographic surface alterations characteristic of cells transformed by type C retroviruses. The morphologic relationship of EIAV and pathologic manifestations of EIAV infection to those of other Retroviridae are discussed.