Effects of Supplementary Methionine and Choline on Tissue Lipides and on the Vascular Structure of Cholesterol-Fed Growing Rats

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Abstract
The influence of choline deficiency, methionine deficiency and a combination of these deficiencies on lipide metabolism and on the development of atherosclerosis in the growing rat has been investigated. Mild aortic changes were produced in male rats by feeding diets high in cholesterol, adequate in choline, and deficient in sulfur-containing amino acids. The various serum lipide fractions were greatly increased in those rats consuming the choline-rich diets. Consequently, the elevation of these constituents appears to be a prerequisite to the production of certain cardiovascular disease. Under the conditions of these experiments the increased hyperlipemia, hypercholesterolemia, and hyperphospholipemia resulting from the ingestion of such diets was partially prevented by DL-methionine supplementation.