Molecular Characterization and Comparison of Simian Immunodeficiency Virus Isolates From Macaques, Mangabeys, and African Green Monkeys
- 1 June 1989
- journal article
- research article
- Published by Wiley in Journal of Medical Primatology
- Vol. 18 (3-4) , 287-303
- https://doi.org/10.1111/j.1600-0684.1989.tb00231.x
Abstract
Simian immunodeficiency virus (SIV)/Mne has been inoculated into three species of macaques and into baboons. Virus was isolated from all the macaques who subsequently died at 15 to 120 weeks (mean 80 weeks) with various manifestations of immune deficiency. Individual animals varied in their viral antibody profile as a function of time after infection. Independent SIV isolates obtained from African green monkeys and magabeys were compared to SIV/Mne for their ability to replicate in lymphocytes and macrophages and with respect to the immunological relatedness of their viral proteins. Antibodies present in human immunodeficiency virus‐2 (HIV‐2)‐infected individuals were readily detected by the virus produced by a single‐cell clone of SIV/Mne.Keywords
Funding Information
- U.S. Public Health Service
- National Institutes of Health (RR0016, N01‐CO‐74102, N01‐CO‐23910)
This publication has 14 references indexed in Scilit:
- Transmission of the Simian Immunodeficiency Virus SIVmne in Macaques and BaboonsJournal of Medical Primatology, 1989
- Isolation and Characterization of a Novel Protein (X-ORF Product) from SIV and HIV-2Science, 1988
- Isolation of simian immunodeficiency virus from african green monkeys and seroepidemiologic survey of the virus in various non‐human primatesInternational Journal of Cancer, 1988
- Seroepidemiologic survey of captive old‐world primates for antibodies to human and simian retroviruses, and isolation of a lentivirus from sooty mangabeys (Cercocebus atys)International Journal of Cancer, 1986
- Isolation of a T-lymphotropic retrovirus from naturally infected sooty mangabey monkeys (Cercocebus atys).Proceedings of the National Academy of Sciences, 1986
- Isolation of an HTLV-III-related retrovirus from macaques with simian AIDS and its possible origin in asymptomatic mangabeysNature, 1986
- Induction of AIDS-Like Disease in Macaque Monkeys with T-Cell Tropic Retrovirus STLV-IIIScience, 1985
- Isolation of T-Cell Tropic HTLV-III-Like Retrovirus from MacaquesScience, 1985
- Characterization of Exogenous Type D Retrovirus from a Fibroma of a Macaque with Simian AIDS and FibromatosisScience, 1984
- Evolution of type C viral genes: evidence for an Asian origin of manNature, 1976