Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein
- 1 March 1990
- journal article
- Published by Springer Nature in Nature
- Vol. 344 (6263) , 219-223
- https://doi.org/10.1038/344219a0
Abstract
Position-effect variegation is the inactivation in some cells of a gene translocated next to heterochromatin, the region of the chromosome that is permanently condensed. The number of copies of the Drosophila gene Suvar(3)7 is a dose-limiting factor in this phenomenon, and seems from its sequence that it encodes a protein with five widely spaced zinc-fingers. This novel arrangement of zinc-fingers could help in packaging the chromatin fibre into heterochromatin, and also reflect a novel method of controlling the expression from DNA domainsKeywords
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