Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB
- 1 August 1988
- journal article
- Published by Springer Nature in Nature
- Vol. 334 (6182) , 494-498
- https://doi.org/10.1038/334494a0
Abstract
A nuclear protein, CREB, has been isolated from rat brain and shown to stimulate transcription of the cyclic AMP-responsive gene somatostatin as a dimer. Biochemical analysis suggests that dimerization and transcriptional efficacy of CREB protein in vitro are regulated by phosphorylation. These findings demonstrate that cellular signals can modulate gene expression by regulating the covalent modification of pre-existing nuclear factors.Keywords
This publication has 16 references indexed in Scilit:
- A cellular protein, activating transcription factor, activates transcription of multiple E1A-inducible adenovirus early promoters.Proceedings of the National Academy of Sciences, 1987
- Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin geneNature, 1987
- Ia binding ligands and cAMP stimulate nuclear translocation of PKC in B lymphocytesNature, 1987
- Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40Nature, 1987
- Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.Proceedings of the National Academy of Sciences, 1986
- Cyclic AMP regulates somatostatin mRNA accumulation in primary diencephalic cultures and in transfected fibroblast cellsJournal of Neuroscience, 1986
- Two distinct transcription factors bind to the HSV thymidine kinase promoter in vitroCell, 1985
- SomatostatinNew England Journal of Medicine, 1983
- Elution of proteins from sodium dodecyl sulfate-polyacrylamide gels, removal of sodium dodecyl sulfate, and renaturation of enzymatic activity: Results with sigma subunit of Escherichia coli RNA polymerase, wheat germ DNA topoisomerase, and other enzymesAnalytical Biochemistry, 1980
- Two-dimensional electrophoresis of proteins of citric acid nuclei prepared with aid of a Tissumizer®Experimental Cell Research, 1973